Mamoru Watanabe Selected Research

Interleukins

1/2016	Epithelial Nuclear Factor-x03BA;B Activation in Inflammatory Bowel Diseases and Colitis-Associated Carcinogenesis.
6/2015	Impaired induction of interleukin 28B and expression of interferon λ 4 associated with nonresponse to interferon-based therapy in chronic hepatitis C.
7/2014	Genetic variation near interleukin 28B and the risk of hepatocellular carcinoma in patients with chronic hepatitis C.
1/2011	Serum interleukin-6 levels correlate with resistance to treatment of chronic hepatitis C infection with pegylated-interferon-α2b plus ribavirin.
1/2007	Bone marrow retaining colitogenic CD4+ T cells may be a pathogenic reservoir for chronic colitis.
2/2006	TH1/TH2-mediated colitis induced by adoptive transfer of CD4+CD45RBhigh T lymphocytes into nude mice.
8/2003	Interleukin-18 overproduction exacerbates the development of colitis with markedly infiltrated macrophages in interleukin-18 transgenic mice.
6/2003	Macrophage-derived IL-18 targeting for the treatment of Crohn's disease.

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Mamoru Watanabe Research Topics

Disease

62	Ulcerative Colitis 04/2024 - 07/2003
49	Colitis 01/2023 - 02/2003
47	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2023 - 11/2002
45	Crohn Disease (Crohn's Disease) 10/2023 - 12/2002
37	Infections 11/2023 - 09/2003
29	Inflammation (Inflammations) 05/2023 - 07/2002
25	Neoplasms (Cancer) 05/2023 - 07/2002
18	Chronic Hepatitis C 05/2019 - 07/2002
8	Colonic Neoplasms (Colon Cancer) 07/2021 - 10/2005
8	Hepatocellular Carcinoma (Hepatoma) 10/2020 - 01/2004
7	Carcinogenesis 12/2019 - 07/2003
6	Tuberculosis (Tuberculoses) 08/2021 - 05/2013
6	Liver Cirrhosis (Hepatic Cirrhosis) 10/2020 - 04/2004
6	Ulcer 03/2020 - 01/2004
6	Fibrosis (Cirrhosis) 11/2017 - 06/2010
6	Hepatitis C 07/2016 - 06/2003
5	Hemorrhage 01/2022 - 12/2015
5	Necrosis 07/2021 - 09/2016
5	Colorectal Neoplasms (Colorectal Cancer) 01/2020 - 07/2003
5	Intestinal Diseases (Diseases, Intestinal) 01/2020 - 12/2011
4	Colitis-Associated Neoplasms 03/2021 - 04/2009
4	Chronic Hepatitis (Chronic Active Hepatitis) 04/2020 - 04/2004
4	Anemia 10/2017 - 11/2010
4	Liver Diseases (Liver Disease) 01/2011 - 04/2004
3	Stomach Neoplasms (Stomach Cancer) 06/2023 - 03/2022
3	Herpes Zoster 01/2023 - 02/2013
3	Wounds and Injuries (Trauma) 11/2022 - 01/2020
3	Disease Progression 06/2019 - 05/2016
3	Hemolytic Anemia 10/2017 - 11/2010
3	Virus Diseases (Viral Diseases) 06/2015 - 12/2007
3	Neoplasm Metastasis (Metastasis) 01/2013 - 10/2005
3	Wasting Syndrome (Wasting Disease) 04/2007 - 10/2003
2	Rheumatoid Arthritis 10/2023 - 01/2017
2	Hypersensitivity (Allergy) 10/2023 - 01/2021
2	Adenocarcinoma 11/2022 - 03/2018
2	Abscess 01/2022 - 09/2006

Drug/Important Bio-Agent (IBA)

18	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 04/2021 - 06/2003
17	Ribavirin (Virazole)FDA LinkGeneric 04/2020 - 04/2004
17	InterferonsIBA 11/2017 - 04/2004
16	Antiviral Agents (Antivirals)IBA 10/2020 - 04/2004
14	Adalimumab (Humira)FDA Link 01/2022 - 03/2012
13	CytokinesIBA 01/2023 - 12/2002
13	Interleukin-7 (Interleukin 7)IBA 11/2013 - 03/2003
12	Infliximab (Remicade)FDA Link 10/2023 - 02/2011
12	Proteins (Proteins, Gene)FDA Link 12/2022 - 01/2005
9	Dextran SulfateIBA 01/2023 - 08/2003
9	Monoclonal AntibodiesIBA 07/2021 - 02/2003
8	vedolizumabIBA 01/2022 - 03/2017
8	Adrenal Cortex Hormones (Corticosteroids)IBA 12/2021 - 01/2007
8	InterleukinsIBA 01/2016 - 06/2003
7	Biomarkers (Surrogate Marker)IBA 01/2023 - 01/2017
6	SteroidsIBA 10/2023 - 08/2006
6	Mesalamine (Mesalazine)FDA LinkGeneric 01/2022 - 07/2013
6	AntibodiesIBA 04/2020 - 09/2003
5	Leucine (L-Leucine)FDA Link 01/2023 - 01/2017
5	Glycoproteins (Glycoprotein)IBA 01/2023 - 01/2017
5	LigandsIBA 01/2023 - 10/2003
5	Immunologic Factors (Immunomodulators)IBA 01/2022 - 03/2011
5	Immunosuppressive Agents (Immunosuppressants)IBA 01/2021 - 11/2002
5	2-mercaptopurineIBA 10/2019 - 05/2013
5	Interferon-alpha (Interferon Alfa)IBA 03/2013 - 09/2005
5	RNA (Ribonucleic Acid)IBA 09/2011 - 09/2003
5	AntigensIBA 10/2005 - 01/2002
4	Tacrolimus (Prograf)FDA LinkGeneric 12/2021 - 02/2011
4	Anti-Bacterial Agents (Antibiotics)IBA 09/2021 - 09/2006
4	Interleukin-12 (IL 12)IBA 07/2021 - 12/2002
4	tofacitinibIBA 01/2021 - 01/2018
4	Budesonide (Pulmicort)FDA LinkGeneric 01/2020 - 01/2018
4	Inosine TriphosphataseIBA 10/2017 - 11/2010
4	Interleukin-6 (Interleukin 6)IBA 01/2016 - 01/2011
3	GLPG0634IBA 11/2023 - 01/2021
3	Biosimilar PharmaceuticalsIBA 10/2023 - 10/2019
3	CT-P13IBA 10/2023 - 10/2019
3	trifluridine tipiracil drug combinationIBA 06/2023 - 04/2023
3	C-Reactive ProteinIBA 05/2023 - 02/2014
3	Serum AlbuminIBA 05/2023 - 10/2013
3	Amino Acids FDA Link 01/2021 - 06/2011
3	Azathioprine (Imuran)FDA LinkGeneric 09/2019 - 11/2016
3	AlbuminsIBA 06/2019 - 09/2015
3	Capsules (Microcapsules)IBA 03/2019 - 01/2014
3	Dextrans (Dextran)FDA Link 01/2018 - 01/2005
3	Type II Tumor Necrosis Factor ReceptorsIBA 01/2016 - 04/2009
3	Immunoglobulin G (IgG)IBA 07/2015 - 08/2003
3	Interleukin-7 Receptors (Interleukin 7 Receptor)IBA 02/2011 - 08/2003
3	Cyclosporine (Ciclosporin)FDA LinkGeneric 02/2011 - 01/2004
3	Messenger RNA (mRNA)IBA 01/2011 - 01/2005
3	Interleukin-18 (Interleukin 18)IBA 08/2003 - 12/2002
2	NivolumabIBA 06/2023 - 03/2022
2	Antineoplastic Agents (Antineoplastics)IBA 05/2023 - 04/2023
2	Janus Kinase 1IBA 01/2023 - 01/2021
2	NickelIBA 12/2022 - 01/2021
2	Collagen Type I (Type I Collagen)IBA 11/2022 - 01/2020
2	CollagenIBA 11/2022 - 01/2020
2	AJM300IBA 01/2022 - 12/2015

Therapy/Procedure

84	Therapeutics 04/2024 - 07/2003
6	Colectomy 08/2023 - 04/2005
6	Transplantation 01/2022 - 07/2002
5	Drug Therapy (Chemotherapy) 04/2023 - 02/2010
3	Cell- and Tissue-Based Therapy (Cell Therapy) 01/2016 - 09/2005
2	Restorative Proctocolectomy 01/2023 - 01/2007